针对阿波利波蛋白-A1的抗体,非酒精性脂肪肝和心血管风险:一个翻译性研究
Sabrina Pagano1,2, Stephan J L Bakker3, Catherine Juillard4
1Division of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Rue Michel Servet 1, 1211, Geneva, Switzerland. Sabrina.Pagano@hcuge.ch.
Journal of translational medicine
|October 5, 2023
概括
针对阿波利波蛋白A-1 (AAA-1) 的自身抗体促进非酒精性脂肪肝疾病 (NAFLD) 的特征,并与心血管疾病 (CVD) 风险有关. 虽然AAA-1影响NAFLD,但脂肪肝指数 (FLI) 独立预测一般人群的高心血管疾病风险.
科学领域:
- 心血管研究研究心血管研究
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一种普遍的疾病,与心血管疾病 (CVD) 发病率和死亡率的增加有关.
- 针对阿波利波蛋白A-1 (AAA-1) 的自身抗体被认为是一种新的心血管疾病风险因素,可能导致炎症和脂质代谢障碍,这是NAFLD病变的关键方面.
研究的目的:
- 调查AAA-1在NAFLD发展中的作用.
- 检查AAA-1和心血管疾病风险在一般人口队列中的关联.
主要方法:
- 实验室 (HepaRG细胞) 和体内 (ApoE-/-小鼠) 模型被用于评估AAA-1对脂质合成,炎症和肝细胞损伤的影响.
- 来自PREVEND队列中的312名个体的血清被分析为AAA-1水平,NAFLD和高CVD风险代理由脂肪肝指数 (FLI) ≥60和弗雷明汉姆风险评分 (FRS) ≥20%分别定义.
主要成果:
- 在实验模型中,AAA-1暴露诱导了NAFLD兼容的表型,包括增加的甘油三合成,肥胖症,炎症和肝细胞损伤.
- 在高FLI的个体中,AAA-1水平与更高的FRS,性酸酶和更低的HDL胆固醇相关.
- 单变量分析显示了AAA-1,FLI和高FRS之间的显著关联;然而,只有FLI成为高心血管疾病风险的独立预测因素 (OR:1.05,95%CI1.01-1.09).
结论:
- 在实验环境中,AAA-1可以诱导与NAFLD一致的表型.
- 在一般人群中,AAA-1,心血管疾病风险和NAFLD标志物之间存在复杂的关系.
- 需要进一步的研究来澄清AAA-1在NAFLD中的确切作用,以及在心血管疾病风险评估中与肝硬化症的相互作用.
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