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基于质谱的依从性监测的样本矩阵:系统的批判性审查

Cathy M Jacobs¹, Lea Wagmann, Markus R Meyer

¹Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Homburg, Germany.

Therapeutic drug monitoring

|October 6, 2023

概括

质谱法 (MS) 有助于粘附性监测,但没有单个样本矩阵是理想的. 选择合适的矩阵取决于物质和监测目标,平衡检测窗口和药理动力学数据.

科学领域:

临床毒理学临床毒理学
分析化学是一种分析化学.
药理学药理学是指药理学的学科.

背景情况:

质谱仪 (MS) 对于临床毒理学中对粘附的分析监测至关重要.
精确检测生物流体中的药物和代谢物对于药物坚持和戒断的监测至关重要.
本研究评估了各种样本矩阵,用于基于MS的依从性监测.

结论:

每个样本矩阵都有独特的优点和缺点,用于遵守监测.
没有单一的矩阵可以作为普遍的黄金标准.
对样本矩阵的知情选择需要对目标物质和具体监测目标提供全面的药理动力学信息.

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