行为疗法与行为疗法加米拉贝格朗50毫克在性活跃的男性与烦人的过度活跃的膀症状之间的比较研究 - 一个多中心,随机研究
Chih-Chieh Lin1,2, Hann-Chorng Kuo3, Jian-Ri Li4
1Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan.
International neurourology journal
|October 6, 2023
概括
使用mirabegron的行为疗法显著改善了过度活跃的膀症状,远远超过单独治疗. 两种治疗都没有影响性活跃男性的勃起功能或射精功能.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度活跃的膀 (OAB) 显著影响生活质量.
- 行为治疗是一种常见的OAB治疗方法.
- 米拉贝格伦是OAB治疗的选择性β3上腺素受体激动剂.
研究的目的:
- 评估与或没有mirabegron的行为治疗对OAB症状和性功能在性活跃的男性患者的治疗效果.
- 评估mirabegron在改善OAB症状方面的潜力及其对性功能的影响.
主要方法:
- 一项4个地点的随机对照试验招募了150名患有OAB的性活跃男性.
- 参与者被随机分配到单独的行为疗法 (n=50) 或mirabegron加行为疗法 (n=100).
- 结果包括OABSS,性功能得分和尿动力学参数,在基线,4周和12周评估.
主要成果:
- 两组在12周后OABSS显著改善.
- 组合组在所有OABSS分值和功能性膀容量方面表现出显著的改善.
- 尿频率和尿失禁子评分在单独行为治疗组中没有显著变化.
- 无论哪个治疗组都没有表现出勃起功能或射精功能的显著变化.
结论:
- 与Mirabegron结合的行为疗法在改善OAB症状方面表现出优异的疗效,与单独的行为疗法相比.
- 两种治疗方法都没有在研究群体中显著改变勃起功能或射精功能.
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