脊柱二叉脊椎儿童自主神经系统活动的变化:一项病例对照研究
Byeong Seon Kim1, Israel Franco2, Yong Seung Lee1
1Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
International neurourology journal
|October 6, 2023
概括
与对照人群相比,脊柱裂变患者表现出自主神经系统功能障碍,在膀填充过程中表现出降低的副交感活动. 这种自主失衡可能会导致脊柱裂变中神经性膀病理生理学.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 心脏病学 心脏病学
背景情况:
- 脊椎裂是一种先天性疾病,通常导致神经性膀和自主神经系统 (ANS) 功能障碍.
- 心率变化 (HRV) 分析是一种评估ANS活动的非侵入性工具.
- 泌尿动力学研究提供了下泌尿道的功能评估.
研究的目的:
- 在泌尿动力学研究中,比较脊柱裂患者和对照组之间的HRV参数.
- 为了评估自主神经系统功能障碍在患有脊柱裂的人群中的程度.
主要方法:
- 在三个尿动力学阶段记录了11名脊柱裂患者和9名对照患者的持续HRV参数:预填充 (P0),填充 (P1) 和最终填充 (P2).
- 对照组是患有膀外流的儿童,他们接受了视频尿动力学研究.
- 分析了特定的HRV指标,包括连续差异的根平均平方,高频 (HF) 和低频 (LF) /HF比率.
主要成果:
- 与对照组相比,脊柱裂患者表现出较低的基线HRV参数 (RMSSD,HF) 和较高的LF/HF比率.
- 在膀填充过程中,对照组的LF/HF比率增加,表明交感激活.
- 相反,脊柱裂患者在填充过程中表现出LF/HF比率的下降和HF值的升高,这表明了变化的副交感和交感活动模式.
结论:
- 脊柱裂患者在膀填充时表现出明显的自主反应,其特点是增加了副交感活动和固定的交感活动.
- 对照组显示,随着膀填充的进展,对同情的占主导地位的转变.
- 这些发现表明,神经神经系统功能障碍,特别是在膀填充期间,与脊柱裂中神经性膀的病理生理学有关.
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