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微生理学构造和系统:生物制造策略,仿生评估方法和生物医学应用
Shuyu Zhang1,2, Guoshi Xu1,3,4, Juan Wu1,3,4
1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, 100101, China.
Small methods
|October 6, 2023
概括
微生理系统 (MPS) 和构造 (MPC) 为药物发现提供了对动物试验的先进替代方案. 需要进一步开发以提高其可靠性和应用忠实性,以实现个性化医疗.
科学领域:
- 生物技术是生物技术.
- 生物医学工程 生物医学工程
- 药物发现 药物发现 药物发现
背景情况:
- 微生理学构造和系统 (MPC) 和微生理学系统 (MPS) 已取得显著的进步,包括有机体和器官芯片平台.
- 生物材料,生物墨水,3D生物打印,微/纳米制造和传感器方面的创新推动了各种生物制造战略.
- MPC和MPS,特别是ADMET的组织芯片,在药物开发和个性化医学中显示出精确,高效和具有成本效益的动物模型替代品.
研究的目的:
- 审查微生理学构造和系统 (MPC) 和微生理学系统 (MPS) 以及它们的应用方面的最新进展.
- 讨论评估这些模型的可靠性,量化技术和利用这些模型的忠实性的挑战.
主要方法:
- 关于微生理学构造和系统 (MPC) 和微生理学系统 (MPS) 的最新文献的审查.
- 分析生物材料,生物墨水,3D生物打印,3D生物制造,微/纳米制造和传感器技术的进展.
- 在药物发现,个性化医学和ADMET研究中应用的评估.
主要成果:
- 在开发各种MPC和MPS方面取得了重大进展,包括有机体和器官芯片平台.
- 这些系统显示出作为药物发现和个性化医学的动物模型替代品的潜力.
- 目前的模型主要侧重于在有限水平上体外复制解剖结构和生理指数.
结论:
- MPC和MPS是一个快速发展的领域,对制药研究有很大的潜力.
- 解决可靠性,量化和忠实性的挑战对于广泛采用至关重要.
- 需要进一步的研究才能充分实现这些先进的体外模型在药物开发和个性化医学方面的功能.
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