向BRD4可以减轻乳腺母细胞瘤的干性和攻击性
Jiaxiang Xie1,2,3, Jingqi Zhang1,2,3, Gan Xiong1,2,3
1Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Oral diseases
|October 6, 2023
概括
odomain-4 (BRD4) 在乳腺母细胞瘤 (AM) 中被上调,导致瘤的进展和复发. 用BET抑制剂抑制BRD4为AM管理提供了一个有前途的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- odomain-4 (BRD4) 是odomain外终端 (BET) 蛋白家族的一员,与瘤进展有关.
- 对于BRD4在罕见的口腔瘤 - - 乳腺母细胞瘤 (AM) 中的作用尚不清楚.
研究的目的:
- 为了研究BRD4在乳腺母细胞瘤中的表达和功能意义.
- 评估在AM中准BRD4的治疗潜力.
主要方法:
- 免疫组织化学评估在AM组织中的BRD4表达.
- 试验室试验评估BRD4枯竭对AM细胞增殖,迁移和入侵的影响.
- RNA测序用于分析BRD4贫的AM细胞中的基因表达特征.
- 来自基因表达总汇 (GEO) 的AM表达数据的生物信息分析.
- 使用患者衍生AM器官的BET抑制剂 (BETi) 疗效的评估.
主要成果:
- 在传统的AM,复发性AM和乳腺癌中,BRD4表达显著上调.
- BRD4 枯竭抑制了AM细胞的增殖,入侵,迁移和瘤性.
- BET抑制剂降低了AM的攻击性,并抑制了患者衍生的AM有机体的生长.
- 生物信息分析表明BRD4通过Wnt和茎结相关途径促进AM的进展.
结论:
- BRD4通过调节Wnt和茎状性通路,促进了乳腺母细胞瘤的攻击性和复发.
- BRD4代表了改善乳腺母细胞瘤管理的潜在治疗标.
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