相关实验视频

Updated: Jul 14, 2025

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model

Published on: August 16, 2020

用弱监督的机器学习来评估骨髓瘤患者的亡:一项试点研究

Christa L LiBrizzi¹, Zhenzhen Wang², Jeremias Sulam²

¹Department of Orthopaedic Surgery, Division of Orthopaedic Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

|October 6, 2023

概括

一个新的机器学习模型准确地计算了骨髓瘤瘤的死亡率,与病理学家的表现相匹配. 这种人工智能工具可以提高这种骨癌的预后准确性.

科学领域:

在瘤学瘤学.
计算病理学计算病理学
人工智能在医学中的应用

背景情况:

百分比亡 (PN) 是骨髓瘤生存的关键预后因素.
目前使用全幻灯片图像 (WSIs) 的病理学家对PN的估计是劳动密集型和可变的.
需要标准化,准确的PN评估方法.

研究的目的:

开发一种机器学习 (ML) 模型,用于计算骨髓瘤中的PN.
为了达到与肌肉骨病理学家可比的准确性.
为了自动化PN估计的劳动密集型过程.

主要方法:

从两个骨髓瘤患者的6个WSIs的回顾性分析.
训练一个弱监督的ML模型,使用瘤和非瘤组织的不完整注释.
将ML模型的PN估计与病理学家使用Pearson的相关性和MAE的估计进行比较.

主要成果:

ML模型实现了平均绝对误差 (MAE) 的15% (不包括异常值的6.4%).
模型和病理学家PN估计显示出强烈的正相关性 (r=0.85).
该模型成功地细分了可行的瘤,死瘤和非瘤组织.

结论:

一个弱监督的ML模型可以准确计算骨髓瘤中的PN.
开发的模型表现出与专家病理学家相似的性能.
预计随着对组织学异质性的加强注释,会有进一步的改善.

关键词:

骨头骨头骨头骨头癌症 / 瘤 / 癌症 / 瘤临床临床临床临床临床临床

更多相关视频

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma

Published on: October 10, 2018

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

相关概念视频

Classification of Bones

Classification of Bones

The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...