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英格列通过BDNF-TrkB-mTORC1信号通路增加突触可塑性来减轻类似抑郁症的表型

Yangyang Xu^1,2, Jie Zhang³, Linyao Yu¹

¹School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, P. R. China.

Journal of cellular and molecular medicine

|October 6, 2023

概括

恩格莱丁是一种天然化合物,通过激活来自大脑的神经营养因子 (BDNF) - 铁酸酶B (TrkB) - 哺乳动物目标的拉巴胺素复合物1 (mTORC1) 途径,并改善前额叶皮层的突触可塑性,在小鼠中表现出抗抑郁作用.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

大型抑郁症 (MDD) 给健康带来了重大挑战,目前的治疗方法也有局限性.
新型抗抑郁药和治疗点是必要的,因为现有的药物疗法的不足和副作用.
恩格莱是一种Smilax glabra根茎的衍生物,已在缺血性中风中表现出有效性,但其抗抑郁药的潜力尚未被探索.

研究的目的:

为了研究抗抑郁药类效应和格莱丁的潜在机制.
评估Engeletin在已建立的小鼠抑郁症模型中的疗效.
探索格莱对前额叶皮层 (PFC) 和相关信号通路的影响.

主要方法:

行为测试包括小鼠的强迫游泳测试 (FST) 和尾部悬浮测试 (TST).
慢性克制压力 (CRS) 鼠标模型模拟抑郁症,用素 (FLX) 作为阳性对照.
分析PFC脊柱密度,与突触可塑性相关的蛋白质和来自大脑的神经营养因子 (BDNF) - 铁氨酸激酶B (TrkB) - 哺乳动物目标的拉巴胺素复合物1 (mTORC1) 途径,使用特定的抑制剂 (ANA-12和拉巴胺素).

主要成果:

恩格莱丁在FST和TST中表现出类似抗抑郁药的活性,但没有影响发动机活动.
恩格莱丁在CRS老鼠抑郁模型中显示出有效性.
在CRS期间,Engeletin增强了PFC中的BDNF-TrkB-mTORC1通路,并逆转了CRS诱导的树突脊柱密度和突触可塑性蛋白的减少.

结论:

英格列丁具有抗抑郁作用.
英格列的抗抑郁作用通过激活BDNF-TrkB-mTORC1信号通路来调节.
恩格莱可提高前额叶皮质的突触可塑性,这表明了抑郁症的新治疗机制.

关键词:

在BDNF-TrkB-mTORC1信号通路中.慢性克制压力的压力英格兰的英格兰人.大型抑郁症主要是抑郁症.前额叶皮层前额叶皮层.突触性可塑性突触性可塑性

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