促进药物输送到关节软骨:从单个到多个策略
Tianyuan Zhao1,2, Xu Li3, Hao Li1,2
1Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing 100853, China.
Acta pharmaceutica Sinica. B
|October 6, 2023
概括
多种药物输送系统为治疗关节软骨 (AC) 损伤和骨关节炎 (OA) 提供了改进的策略. 顺序和协同方法对于有效的软骨再生至关重要,克服单剂疗法的局限性.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药物输送系统 药物输送系统
背景情况:
- 关节软骨 (AC) 损伤可能导致骨关节炎 (OA) 由于自我修复能力差.
- 目前的关节内药物递送系统旨在增强治疗局部化和受控释放.
- 单剂传递系统难以应对软骨病理和异质结构的多因素性质.
研究的目的:
- 审查关节软骨疾病的单一药物输送策略.
- 突出多种药物输送应用在软骨再生方面的进展.
- 激发未来关节内药物输送系统 (DDS) 的合理设计.
主要方法:
- 对AC疾病的单一药物输送系统的综合文献综述.
- 分析新兴的多种药物输送策略,包括顺序和协同方法.
- 检查药物输送中的空间分布和异质再生方面.
主要成果:
- 单剂输送系统在实现全面的软骨再生方面存在局限性.
- 多种药物输送系统通过对病理过程的顺序向展示了潜力.
- 协同准和空间分布是高级DDS的关键考虑因素.
结论:
- 顺序的药物输送策略对于解决软骨损伤的复杂性至关重要.
- 多种药物输送系统为模仿自然生物合成和实现完全软骨再生提供了一个有希望的途径.
- 未来的研究应该专注于设计复杂的DDS,以有效治疗AC疾病.
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