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自我报告的疲劳和冠状动脉疾病之间的因果关系:双向的双样本孟德尔随机化分析
Xiaoyi Qi1,2, Shijia Wang1, Liangxian Qiu1
1Departments of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China.
Frontiers in psychiatry
|October 6, 2023
概括
这项研究发现,疲劳可能会导致冠状动脉疾病 (CAD) 的风险增加. 虽然疲劳会影响冠状动脉动脉样硬化,心肌梗塞和冠状动脉心脏病,但由于潜在的变性,建议谨慎使用.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,疲劳与冠状动脉疾病 (CAD) 有关.
- 疲劳和CAD之间的因果关系仍然不确定.
- 研究遗传倾向可以阐明因果关系.
研究的目的:
- 调查自我报告的疲劳和冠状动脉疾病 (CAD) 之间的潜在因果关系.
- 评估疲劳对特定CAD结果的因果关系,如冠状动脉动脉样硬化 (CAA),心肌梗塞 (MI) 和冠状动脉心脏病 (CHD).
- 为了检查从CAD到疲劳的潜在反向因果关系.
主要方法:
- 采用双向门德尔随机化 (MR) 研究设计.
- 全基因组关联研究 (GWAS) 的数据被用于遗传仪器变量.
- 逆变量加权 (IVW) 方法是主要分析方法,加上加权中位数,MR-Egger和MR-PRESSO用于灵敏度分析和变性评估.
主要成果:
- 自我报告的疲劳对冠状动脉动脉样硬化 (OR 1.047),心肌梗塞 (OR 1.027),冠状动脉心脏病 (OR 1.037) 有因果关系.
- 从CAD到疲劳没有发现任何显著的反向因果关系.
- 在一些分析中,MR-PRESSO发现了水平变性,需要谨慎的解释.
结论:
- 门德尔随机分析表明,自我报告的疲劳与冠状动脉疾病风险增加之间存在因果关系.
- 研究结果表明,疲劳可能是导致CAD发展的一个因素.
- 在解释因果估计时,水平形的存在需要仔细考虑.
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