抗关节炎活性和炎症媒介调节传统阿吉莫达迪丘尔纳对关节炎的影响实验模型
Vikash Sharma1, Shiv Shankar Shukla2, Bina Gidwani2
1Department of Pharmacology, Columbia Institute of Pharmacy, Raipur, Chhattisgarh, India.
Journal of pharmacopuncture
|October 6, 2023
概括
阿贾莫达迪·丘尔纳 (AC) 通过减少大鼠的脚胀和炎症,显示出显著的抗关节炎作用. 用AC治疗也有助于使免疫反应正常化,这表明它对关节炎的治疗潜力.
科学领域:
- 艾尔韦达医学是一种医学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类风湿性关节炎是一种慢性炎症性疾病.
- 完整的弗洛恩德辅助剂 (CFA) 诱导的关节炎是研究炎症性关节炎症的常见动物模型.
- 阿吉莫达迪丘尔纳 (AC) 是一种传统的阿育吠陀配方,用于治疗各种疾病.
研究的目的:
- 评估阿贾莫达迪·丘尔纳 (AC) 的抗关节炎活性.
- 评估AC对Wistar大鼠的完整弗洛恩德辅助剂 (CFA) 诱导的关节炎的影响.
主要方法:
- 在Wistar大鼠中使用CFA注射诱导了关节炎.
- 动物在21天内接受了两剂AC (AC-1:200 mg/kg,AC-2:400 mg/kg) 的治疗.
- 测量了脚,关节炎得分,血液学参数 (红血细胞,白血细胞,ESR,HB),以及IL-6和TNF-α的血清水平.
主要成果:
- 治疗AC-2显著减少了脚的胀,在第21天的值接近对照组的值.
- 与对照组相比,接受AC治疗的老鼠的关节炎得分明显较低.
- AC治疗减少了炎症,降低了血清IL-6和TNF-α水平,并改善了血液学参数.
结论:
- 阿吉莫达迪丘尔纳 (AC) 具有显著的抗关节炎活性.
- AC的抗关节炎作用与调节幽默性免疫反应有关.
- 作为治疗关节炎的治疗剂,AC显示出潜在的潜力.
相关概念视频
01:20The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
01:28Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
01:21Rheumatic Heart Disease III: Medical Management
11
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
11
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
178
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
178
01:29Inflammatory Bowel Disease IV: Pharmacological Management
137
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
137