高动态范围的3D运动跟踪使用循环扫描与光学连贯性断层扫描的循环扫描
Senyue Hao1, Marcello Magri Amaral2,3, Chao Zhou1,2
1Department of Electrical & Systems Engineering, Washington University in Saint Louis, USA.
Biomedical optics express
|October 6, 2023
概括
这项研究引入了一种新的循环光学连贯断层扫描 (OCT) 方法,以精确追踪生物样本运动. 这种技术使得精确的运动补偿能够对活体主体进行增强的微观和宏观成像.
科学领域:
- 生物医学成像技术 生物医学成像技术
- 光学物理学 光学物理学
- 显微镜的使用方法
背景情况:
- 来自生理过程 (心跳,呼吸,静止) 的运动工件显著降低了活体对象成像.
- 精确跟踪生物样本运动对于高分辨率显微镜和宏观成像应用至关重要.
研究的目的:
- 开发和验证一种方法,用于精确跟踪生物样本中横向和轴向运动.
- 为了实现积极的运动补偿,以提高体内成像质量.
主要方法:
- 使用圆形光学连贯性断层扫描 (OCT) 扫描来捕捉样品的运动.
- 实现了循环扫描模式设置的自适应控制,以优化测量.
- 应用跨框架和内框架分析,用于快速,高精度的运动量化.
主要成果:
- 成功跟踪生物样本运动在广泛的速度范围 (微米/秒到厘米/秒).
- 实现了运动大小和方向的快速和高精度测量.
- 证明了实时运动补偿的潜力.
结论:
- 开发的循环OCT方法为生物样本提供了准确的运动跟踪.
- 这种技术构成了先进主动运动补偿策略的基础.
- 未来的in vivo微观和宏观成像将从这种运动校正方法中受益.
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