低老年人营养风险指数预测肝硬化患者的预后不佳:一项回顾性研究
Hiroshi Kamioka1, Chisato Saeki1,2, Akiyoshi Kinoshita3
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Frontiers in nutrition
|October 6, 2023
概括
老年营养风险指数 (GNRI) 有效预测肝硬化患者的长期存活率. 低GNRI得分表明死亡风险较高,突出显示其在评估预后方面的有用性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 老年病的医生 老年病的医生
背景情况:
- 营养不良是肝硬化的重要并发症,增加肝脏疾病事件和死亡率的风险.
- 评估营养状况对于治疗肝硬化患者至关重要.
研究的目的:
- 评估老年营养风险指数 (GNRI) 作为肝硬化患者长期预后的预测指标.
- 确定GNRI是否可以识别高死亡风险的患者.
主要方法:
- 一项对266名肝硬化患者的回顾性研究,根据基线GNRI得分进行分类 (风险≤98与无风险>98).
- 组之间的累积生存率的比较.
- 考克斯比例危险回归分析以确定死亡率预测因素.
主要成果:
- 低GNRI评分与查尔德-普格评分,MELD评分和Mac-2结合蛋白质糖化异构体相反相关.
- 低GNRI是整体队列中死亡率的独立预测因子,补偿和不补偿肝硬化.
- 在GNRI风险组的患者的累积存活率明显较低.
结论:
- 老年营养风险指数 (GNRI) 是一个简单而有效的工具,用于预测肝硬化患者的长期预后.
- 低GNRI与补偿和不补偿肝硬化症的不良结果有关.
- GNRI可以指导营养干预措施,以改善患者的治疗结果.
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