癌症免疫治疗生物标志物的进展
Xuwen Lin1,2, Chenyu Zong1,3, Zhihan Zhang1
1Department of Pulmonary and Critical Care Medicine Peking University Shenzhen Hospital Shenzhen Guangdong Province China.
MedComm
|October 6, 2023
概括
预测生物标志物对于优化癌症免疫治疗至关重要. 本综述涵盖了PD-L1,MSI和TMB等当前生物标志物,以及为更好的治疗选择和降低毒性而出现的新策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 癌症免疫疗法,特别是检查点抑制剂是主要的治疗方法,但缺乏一致的持久反应.
- 组合疗法增加了与免疫相关的不良事件,需要预测生物标志物来进行个性化治疗.
研究的目的:
- 审查癌症免疫疗法预测生物标志物的当前环境.
- 讨论已建立的生物标志物 (PD-L1,MSI,TMB) 和新的策略.
- 探索系统性和非侵入性免疫标记,以预测治疗结果.
主要方法:
- 关于癌症免疫治疗中预测生物标志物的当前数据的文献综述.
- 对已确定的生物标志物的分析:瘤编程细胞死亡连接体1 (PD-L1),微卫星不稳定性 (MSI) 和瘤突变负担 (TMB).
- 探索新的生物标志物策略,包括瘤信号,表观遗传调节和全身免疫标志物.
主要成果:
- 已建立的生物标志物 (PD-L1,MSI,TMB) 显示出可变性和异质性,限制了它们的预测能力.
- 新兴的策略包括瘤信号传递,表观遗传调节和全身免疫标记.
- 外周和肠道免疫标记提供了非侵入性预测潜力.
结论:
- 在癌症免疫治疗中,对经过验证的预测生物标志物有着显著的未满足的需求.
- 需要采用综合方法,整合各种生物标志物,包括全身和肠道微生物群.
- 对新型生物标志物的进一步研究对于优化免疫疗法的有效性和安全性至关重要.
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