口腔植物与pemphigus vulgaris的潜在相关性 - 一项病例对照研究
Bing-Jie Li1, Wen-Xiu He1, Hong Hua1
1Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China.
Journal of dental sciences
|October 6, 2023
概括
口腔植物的变化与pemphigus vulgaris (PV) 有关. 像Prevotella这样的特定细菌的数量增加,而其他细菌的数量减少,这表明失生菌有助于PV的发展.
科学领域:
- 口腔微生物组研究
- 免疫皮肤学 免疫皮肤学
- 微生物的病原发生.
背景情况:
- 口腔植物在与免疫相关的疾病中起作用.
- 杆菌 (Pemphigus vulgaris,简称PV) 是一种自身免疫性水泡性疾病,可能与口腔微生物群有关.
研究的目的:
- 在pemphigus vulgaris患者的口腔菌群的特征.
- 分析口腔植物和PV之间的相关性.
- 探索与口腔微生物组相关的PV发展的潜在机制.
主要方法:
- 病例对照研究比较了22名未经治疗的PV患者和12名健康对照 (HC).
- 使用16S rRNA Illumina MiSeq高通量测序进行唾液微生物组分析.
- 基因和基因组的京都百科全书 (KEGG) 对代谢差异的途径分析.
主要成果:
- 与HC相比,PV患者的整体口腔菌群丰度明显较低.
- 在PV患者中增加了Prevotella和Agrobacterium的相对丰度.
- 在PV患者中,Neisseria,Lautropia和Fusobacterium的丰度降低.
- 在PV中观察到Prevotella丰度和血清Dsg3水平之间的线性相关性.
- 九个KEGG代谢途径的显著差异,包括N-糖甘生物合成和代谢.
结论:
- 在PV患者的口腔植物表现出特有的改变,特别值得注意的是Prevotella物种.
- 口腔微生物组的失生症与pemphigus vulgaris的发生和发展有关.
- 受影响的代谢途径,如N-甘氨酸生物合成,可以提供对PV病原体的见解.
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