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Updated: Jul 14, 2025

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A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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嗅觉功能,神经纤维光链和认知轨迹:上海衰老研究的12年后续研究
Zhenxu Xiao1,2,3, Wanqing Wu1,2,3, Xiaoxi Ma1,2,3
1Institute of Neurology Huashan Hospital Fudan University Shanghai China.
Alzheimer's & dementia (Amsterdam, Netherlands)
|October 6, 2023
概括
嗅觉功能障碍 (OD) 与高血神经丝光链 (NfL) 结合,显著预测老年人的长期认知能力下降. 这种组合可以识别出未来认知恶化风险较高的个体.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 嗅觉功能障碍 (OD) 越来越被认为是神经退行性疾病的早期迹象.
- 神经纤维光链 (NfL) 是神经元损伤的标志物,但其在修改OD与认知衰退的关联中的作用尚不清楚.
研究的目的:
- 调查血液中神经丝光链 (NfL) 水平是否会改变嗅觉功能障碍 (OD) 和长期认知衰退之间的关系.
- 根据嗅觉功能和NfL水平,识别高风险的认知恶化老年人.
主要方法:
- 来自上海衰老研究的1125名非痴呆老年人被评估了12年来嗅觉 (嗅探棒) 和认知功能 (MMSE,TICS-40).
- 测量了血液中NfL水平,并将其分为低组和高组.
- 认知衰退是由痴呆症诊断,病历或MMSE得分显著下降所定义的.
主要成果:
- 嗅觉功能障碍 (OD) 与MMSE分数的急剧下降和认知能力下降的风险增加有关,但仅在高血NfL患者中.
- 患有OD和高NfL的参与者表现出最高的认知能力下降风险 (调整HR:2.43).
结论:
- 高血NfL度可能会加剧嗅觉功能障碍对认知轨迹的影响.
- 结合OD和高NfL作为潜在的指标,用于识别老年人在未来认知恶化风险较高的潜在指标.
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