一个Salmonella Pullorum爆发,在成年层中出现神经症状,并使用全基因组测序进行爆发调查
Robert Jan Molenaar1, Remco Dijkman1, Christiaan Ter Veen1
1Royal GD, Deventer, the Netherlands.
Avian pathology : journal of the W.V.P.A
|October 6, 2023
概括
在Salmonella Pullorum疫情中观察到大脑颗粒瘤和神经征兆. 骨髓是隔离沙门氏菌Pullorum的关键组织,而植物遗传学分析证实了疫情的克隆性.
科学领域:
- 兽医微生物学 兽医微生物学
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 沙门氏菌 (Salmonella Pullorum) 感染可以导致家禽显著的发病率和死亡率.
- 禽类疫情中的神经症状需要进行彻底的病因学调查.
- 准确的诊断对于管理羊群中的沙门氏菌 (Salmonella Pullorum) 爆发至关重要.
研究的目的:
- 调查与沙门氏菌 (Salmonella Pullorum) 爆发相关的病理发现和病因病原体.
- 评估用于检测沙门氏菌Pullorum的诊断方法.
- 在疫情爆发期间鉴定沙门氏菌Pullorum分离物的遗传相关性.
主要方法:
- 对受影响的鸟类进行尸检和组织病理学检查,重点关注神经组织.
- 从包括骨髓在内的各种组织中细菌学分离和识别Salmonella Pullorum.
- 使用快速板块凝结试验进行血清检测,以检测疫苗群中的抗体.
- 对Salmonella Pullorum分离物的植物遗传学分析以确定克隆性.
主要成果:
- 大脑颗粒瘤被确定为一个重要的病理发现.
- 神经症状与大脑颗粒瘤的存在相关.
- 骨髓被证明是一种高度有效的组织,用于隔离沙门氏菌.
- 遗传学分析表明,疫情分离物之间存在克隆关系,这表明有共同的来源或传播事件.
- 快速板结合试验有效检测疫苗接种的家禽群中的抗体.
结论:
- 沙门氏菌Pullorum感染可以表现为由于大脑颗粒瘤形成的神经症状.
- 骨髓是有效隔离沙门氏菌 (Salmonella Pullorum) 的关键样本地点.
- 植物遗传学分析是确认克隆性和了解沙门氏菌普勒勒疫情传播动态的一个有价值的工具.
- 血清学测试有助于监测疫苗接种后群体免疫力.
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