马的右背大肠炎:对35例病例的多中心回顾性研究
Jordan Flood1, David Byrne2, Jennifer Bauquier3
1School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia.
Journal of veterinary internal medicine
|October 6, 2023
概括
马的右背结肠炎 (RDC) 通常是由非类固醇抗炎药物 (NSAID) 过量服用引起的. 对长期接受NSAID治疗的马来说,血清白蛋白的监测至关重要,因为RDC具有显著的死亡率.
科学领域:
- 马类内部医学 马类内部医学
- 兽医胃肠病学 兽医胃肠病学
- 动物中的药理学.
背景情况:
- 右背大肠炎 (RDC) 是一种严重的,往往致命的,在马中失去蛋白质的肠道病变.
- 它主要与非类固醇抗炎药物 (NSAIDs) 的使用有关.
研究的目的:
- 详细说明RDC马的标志,NSAID使用,临床症状,诊断结果,治疗方法和结果.
- 确定影响RDC诊断的马的生存率的因素.
主要方法:
- 一个追溯的案例系列涉及35匹被诊断患有RDC的马在7个澳大利亚马医院.
- 纳入标准要求确定的或假定的诊断与RDC和至少三种:低蛋白质血/低蛋白质血,腹 (不包括传染病原因),结肠与其他原因排除,或右背结肠加厚在超声波.
- 描述性统计和单变物流回归被用来分析数据和生存因素.
主要成果:
- 在已知剂量的情况下,在84%的病例中发现了NSAID过量使用.
- 常见的临床症状包括腹 (69%),结肠痛 (61%) 和心动减速 (53%).
- 关键的临床病理学发现是低albuminemia (83%),低血 (79%) 和高乳酸血 (77%). 在77%的病例中,通过超声波观察到右背结肠的加厚.
- 总体病例死亡率为43%. 心率增加,细胞密集体积和异常的粘膜在呈现时与降低生存几率有关.
结论:
- 过量服用NSAID是马中RDC的常见前体.
- 对于接受延长NSAID治疗的马来说,建议监测血清白蛋白水平.
- 对于RDC的整体预测仍然保持谨慎公正.
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