通过观察管理的口腔上皮质质变形的临床结果与切除相比
Christopher Bernard1, Jasper Zhongyuan Zhang2,3, Hagen Klieb4
1Division of Oral & Maxillofacial Surgery, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Head & neck
|October 6, 2023
概括
完全切除口腔上皮质质变形 (OED) 的手术并没有减少恶性转变,但导致更早的癌症诊断和更好的生存率. 建议进行更广泛的组织采样,以改善口腔癌的结果.
科学领域:
- 口腔瘤学 在口腔瘤学
- 口腔病理学 口腔病理学
背景情况:
- 口腔潜在恶性疾病,如口腔上皮质发育不良 (OED),具有进展为口腔癌的显著风险.
- 目前对OED的管理策略包括通过活检或外科切除进行监测,这提出了临床挑战.
研究的目的:
- 评估OED完全外科切除对恶性转变率的影响.
- 为了确定手术切除是否会影响OED病例的生存结果,这些病例进展到恶性瘤.
主要方法:
- 在2009年至2016年期间,对155名被诊断为OED的患者进行了回顾性审查.
- 随访至2022年1月,以评估疾病进展和患者的结果.
- 通过观察管理的病变与手术切除之间的结局的比较.
主要成果:
- 整体OED恶性转变率为27% (年率为6.4%).
- 与观察相比,手术切除并没有降低恶性转变的速率 (27对25例).
- 手术切除与诊断时较低的瘤分期和改善的生存结果有关.
结论:
- 完全切除OED的手术并不能降低转化为口腔癌的风险.
- 外科手术治疗OED与早期癌症检测和提高患者存活率有关.
- 建议增加组织采样,以改善口腔癌诊断和患者的治疗结果.
相关概念视频
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Barrett Esophagus-II: Clinical Manifestations and Management
172
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
172
Barrett Esophagus-I: Introduction
107
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
107
Esophageal Strictures-II: Clinical Features and Management
86
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
86
Assessment of the Mouth
238
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
238


