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Updated: Jul 15, 2026

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

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在卵巢癌中通过多重分析识别了两个免疫亚型和四个枢纽免疫相关基因

Qin Tang1, Haojie Zhang2, Rong Tang3

  • 1Department of Obstetrics and Gynecology, The Jingmen Center Hospital, Jingmen, PR China.

Medicine
|October 6, 2023
PubMed
概括

这项研究确定了两个卵巢癌 (OV) 免疫亚型,高免疫群体的生存率更好. 发现了四个关键的免疫相关基因 (IRG),为OV免疫疗法提供了潜在的治疗点.

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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