对于NSCLC中PD-1/PD-L1抑制剂的瘤突变负荷的预测值:一个元分析
Wenjie Li1, Yanjun Zhao, Hongjun Zhang
1Department of Respiratory and Critical Care Medicine, Xi'an Chest Hospital, Chang'an District, Xi'an, Shanxi, China.
Medicine
|October 6, 2023
概括
高瘤突变负担 (TMB) 预测非小细胞肺癌患者治疗PD-1/PD-L1抑制剂的无进展生存率更好,但响应率更低. 它在整体生存中的作用需要更多的研究.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 基因组学就是基因组学.
背景情况:
- 非小细胞肺癌 (NSCLC) 治疗疗效不同.
- 编程死亡1 (PD-1) /编程死亡干1 (PD-L1) 抑制剂是关键疗法.
- 瘤突变负担 (TMB) 是一个潜在的预测生物标志物.
研究的目的:
- 评估TMB与治疗结果之间的关联.
- 评估TMB在NSCLC中对PD-1/PD-L1抑制剂治疗的预测价值.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆的系统文献搜索.
- 10个随机对照试验的元分析.
- 纽卡斯尔-太华质量评估规模.
主要成果:
- 高的TMB显著改善了无进展生存率 (PFS).
- 高的TMB与降低的整体响应率 (ORR) 相关.
- 在高和低TMB组之间,整体存活率 (OS) 没有显著差异. 没有检测到出版偏差.
结论:
- 在接受PD-1/PD-L1抑制剂的NSCLC患者中,高TMB可以预测改善PFS和降低ORR.
- 需要进一步的研究来澄清TMB在整体生存中的预测作用.
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