修改后苏安佐伦 (Suanzaoren) 开用于治疗伴随性失眠症状的中风后认知障碍:一项临床试验
Mingjin Zhu1, Guoyua Pan1, Fang Luo1
1Department of Rehabilitation Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Medicine
|October 6, 2023
概括
修改后的Suanzaoren脱 (M-SZRD) 改善了中风患者的认知功能,比佐洛皮德姆更有效地治疗失眠. 虽然这两种治疗都有助于睡眠,但M-SZRD对情绪和激素调节都有好处.
科学领域:
- 神经学 神经学
- 综合医学是一个整体医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 脑卒中后的认知障碍和失眠是普遍存在且具有挑战性的并发症.
- 修改后的苏安索伦 (M-SZRD) 是一种传统的草药药物,用于治疗这些疾病.
- 目前对伴随性脑卒中后认知障碍和失眠的治疗选择有限.
研究的目的:
- 为了评估M-SZRD与皮相比在治疗脑卒中后认知障碍与失眠的疗效.
- 评估M-SZRD对睡眠质量,认知功能,情绪和荷尔蒙平衡的影响.
- 调查M-SZRD的潜在作用机制.
主要方法:
- 一项随机对照试验,涉及80名患有中风后认知障碍和失眠的参与者.
- 参与者被分配接受M-SZRD或佐尔皮4周.
- 评估包括认知测试,睡眠质量评估,情绪尺度和激素水平测量 (HPA和HPT轴).
主要成果:
- 与佐尔皮相比,M-SZRD显著改善了认知功能 (P = .006).
- 这两种治疗方法对失眠症状产生了类似的影响 (P = .323).
- M-SZRD在降低皮质醇水平和改善无血清三铁氨酸 (FT3) 水平方面表现出卓越的效果.
结论:
- 在患有中风后认知障碍和并发性失眠的患者中,M-SZRD是一种更有效的治疗方法来增强认知功能.
- M-SZRD的治疗益处可能与其对下丘脑-垂体-上腺和下丘脑-垂体-甲状腺轴的调节有关.
- M-SZRD为管理复杂的中风后神经和睡眠障碍提供了一个有希望的替代方案.
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