在全国大范围前性队列中,教育程度和癌症发病率
James M Hodge1, Alpa V Patel1, Farhad Islami2
1Department of Population Science, American Cancer Society, Atlanta, Georgia.
概括
更高的教育程度与较低的癌症发病率有关,特别是在男性中. 这种关联因癌症部位而异,并受到行为风险因素的影响,突出了针对性干预的需要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 健康的社会决定因素
背景情况:
- 教育程度是健康的关键社会决定因素,也是社会经济地位的代表.
- 虽然与癌症死亡率有关,但与特定癌症发病率的关联是可变的.
- 了解这种关系对于公共卫生政策和癌症预防策略至关重要.
研究的目的:
- 调查教育程度与特定地点癌症发病率之间的关联.
- 为了调整已知的癌症风险因素在一个大型的潜在队列.
- 为了确定教育差异最明显的特定癌症部位.
主要方法:
- 来自美国癌症协会的癌症预防研究-II营养队列的大型潜在队列 (n=148,965) 的分析.
- 在基线包括没有癌症的参与者,在1992年至2017年间进行了跟踪.
- 利用考克斯的比例危险回归模型来根据教育水平估计癌症风险.
主要成果:
- 在男性中,教育程度和年龄调整后的癌症发病率之间观察到反向关联,但不是女性.
- 在多变量调整后,针对特定癌症部位的显著关联包括男性的结肠,直肠和肺癌,女性的肺癌和乳腺癌.
- 调整行为风险因素减轻了这些关联中的大多数.
结论:
- 教育成就与整体和特定地点的癌症风险有关.
- 教育水平对癌症风险的影响在很大程度上是由相关的行为风险因素介导的.
- 针对教育程度较低的个体的干预措施可能是预防癌症的关键政策考虑因素.
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