身体炼对化学治疗乳腺癌患者MRI评估脑输液的影响:随机对照试验
Emmie W Koevoets1,2, Jan Petr3,4,5, Evelyn M Monninkhof1
1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Journal of magnetic resonance imaging : JMRI
|October 6, 2023
概括
这项研究发现,运动并没有改善认知问题乳腺癌患者的大脑血流 (CBF). 虽然改善的身体健康与CBF变化相关,但记忆功能没有受到显著影响.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 运动科学 运动科学
背景情况:
- 认知障碍是接受化疗的乳腺癌患者常见的担忧.
- 运动是一种潜在的干预措施,但它对大脑血流 (CBF) 和认知机制的影响仍未得到充分研究.
研究的目的:
- 研究结构化运动干预对乳腺癌幸存者经历认知困难的CBF的影响.
- 为了确定干预后CBF和记忆功能的变化之间的关系.
主要方法:
- 一项前性研究涉及181名患有认知问题和身体活动低的乳腺癌患者.
- 参与者被随机分配到一个为期6个月的监督有氧和力量训练计划或对照组.
- 使用3T 2D回声平面伪连续动脉旋转标签测量脑血流 (CBF),并对身体健康和记忆进行评估.
主要成果:
- 与对照组相比,运动组在体能 (VO2峰值) 中显著改善.
- 没有观察到对整个大脑或区域灰质CBF的显著干预效应.
- 身体健康的变化与CBF的变化有积极的关联,但CBF变化与记忆表现没有相关性.
结论:
- 在患有认知障碍的乳腺癌患者中,长达6个月的运动干预并没有改变大脑血流 (CBF).
- 虽然身体健康的改善与CBF有关,但这并没有转化为该人群中增强的记忆功能.
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