肠壁加厚与缺乏补偿性肝硬化症的长期结果之间的关联
Xueying Wang1,2, Min Ding1,3, Weiwei Wang1,4
1Liver Cirrhosis Study Group, Department of Gastroenterology, The General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.
Advances in therapy
|October 6, 2023
概括
结肠壁在结肠和直肠的加厚,而不是小肠,预测肝硬化患者的进一步减补. 这一发现有助于评估肝硬化管理的长期结果.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 放射学和成像学 放射学和成像学
背景情况:
- 肠壁加厚是肝硬化患者常见的发现.
- 它对长期结果的影响仍未得到充分研究.
研究的目的:
- 调查肠壁厚度与不补偿性肝硬化症的长期结果之间的关联.
- 为了确定特定的肠道段,其壁厚度预测进一步的脱补偿和死亡率.
主要方法:
- 对118名缺乏补偿的肝硬化患者进行了回顾性分析.
- 计算机断层扫描 (CT) 成像测量小肠和结肠部分的最大壁厚.
- X-tile软件用于确定风险预测的最佳截止值.
- 纳尔逊-阿伦累积风险分析和竞争风险分析,以评估结果.
主要成果:
- 上升结肠 (≥11.7毫米),横结肠 (≥3.2毫米) 和直肠 (≥7.2毫米) 壁厚度显著与更高的进一步脱补偿率相关.
- 这些结直肠细分是进一步脱补偿的独立预测因素.
- 小肠和西格结肠壁厚度没有预测脱补偿.
- 在任何肠段壁厚度和死亡率之间没有发现显著的关联.
结论:
- 结肠直肠壁加厚,特别是在上升结肠,横结肠和直肠,是肝硬化中进一步减补的重要预测因素.
- 小肠壁厚度不是这种人群中脱补偿或死亡的可靠预测指标.
- CT评估的结直肠壁厚度可以作为一种有价值的工具,用于预后肝管理.
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