热带高海拔地区和成年人的严重喘:室内灰尘虫敏感性和表型分布
Carlos A Torres-Duque1,2, Abraham Alí-Munive1,2, Diego Severiche-Bueno1,2
1Asmaire Program and Departamento de Investigación, Fundación Neumológica Colombiana, Bogotá, Colombia.
概括
高海拔的热带环境在过敏/形表型的严重喘患者中显示出高家庭粉尘虫 (HDM) 敏感性. 这与非热带地区形成鲜明对比,这表明位置影响喘触发因素.
科学领域:
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
- 环境健康 环境健康
背景情况:
- 在热带地区高海拔地区 (HA) 严重喘 (SA) 患者的室内粉尘虫 (HDM) 敏感性和喘表型的数据有限.
- 喘表型分布在热带HA地区与温带或低海拔地区相比可能有所不同.
研究的目的:
- 在哥伦比亚波哥大,一个热带高海拔城市 (2640米) 的严重喘 (SA) 的成年人的特征.
- 调查喘表型的分布,包括过敏/性 (AA) 和性 (EOS),以及在这个人群中对HDM敏感性的分布.
主要方法:
- 在波哥大对129名严重喘门诊患者进行了观察性,横截面研究.
- 收集的数据包括临床病史,精神测量,总IgE,血液中乙酸氨基和皮肤刺伤测试 (SPT) 检测HDM过敏原.
- 现象类型定义为过敏/形 (IgE ≥100 IU/mL和/或阳性SPT),乙酸性 (血液乙酸性细胞≥300细胞/μL),2型高 (AA和/或EOS) 和2型低 (非AA/非EOS).
主要成果:
- 这项研究包括129名严重喘患者 (79.8%为女性).
- 现型分布:过敏性/性 (AA) 61.2%,生性 (EOS) 37.2%,高2型 72.1%,低2型 27.9%.
- 在AA患者中,87%的人患有HDM敏感性;34.9%的人没有eosinophilic. 观察到表型之间存在显著的重叠.
结论:
- 在热带高海拔城市的过敏/热性严重喘患者中发现了高频率的HDM敏感化,与非热带HA地区不同.
- 观察到异性表型的频率略低,与低海拔地区相比,表型分布没有其他显著差异.
- 热带地区的位置可能会影响高海拔对HDM度和过敏性的影响,可能会改变喘表型.
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