在COVID-19之后的自身免疫和自身炎症性结缔组织疾病
Sung Ha Lim1, Hyun Jeong Ju2, Ju Hee Han3
1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
JAMA network open
|October 6, 2023
概括
COVID-19 感染显著增加了发展自身免疫和自身炎症结合组织疾病的风险. 长期患者管理应包括在SARS-CoV-2诊断后对这些疾病进行查.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 报道了COVID-19后出现的多种自身免疫和自身炎症性疾病的病例.
- 在COVID-19之后,这些疾病的发病率和量化风险仍未得到充分研究.
研究的目的:
- 调查COVID-19感染后自身免疫和自身炎症结合组织疾病的发生率和风险.
- 为了确定特定的疾病,并评估COVID-19严重程度的影响.
主要方法:
- 使用全国韩国卫生数据 (2020年10月至2021年12月) 进行了以人口为基础的回顾性队列研究.
- 包括被诊断为COVID-19的个人 (PCR确认) 和对照组.
- 在逆概率加权后使用多变量考克斯比例危险分析来平衡32个共变量.
主要成果:
- 在COVID-19组 (354,527个人) 显示较高的风险白,白总体,抗中性细胞质抗体相关的血管炎,克罗恩氏病和沙尔科伊多斯.
- 观察到的风险增加是总体脱发,牛皮,白,血管炎,克罗恩病,性结肠炎,类风湿性关节炎,成人开始的斯蒂尔病,肖格伦综合征,化性脊髓炎和肉类发病,特别是在严重的COVID-19的情况下.
结论:
- COVID-19与发展自身免疫和自身炎症结合组织疾病的实质性风险有关.
- 对COVID-19患者的长期管理应包括对这些新出现的疾病的评估.
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