普罗波对心率的影响及其与人类皮质缓慢波的合
Marco S Fabus1, Jamie W Sleigh2, Catherine E Warnaby1
1Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, and Nuffield Division of Anaesthetics, University of Oxford, Oxford, United Kingdom.
普罗波麻醉剂以剂量依赖的方式增加心率,可能是通过减少副交感活动. 在普罗波注入过程中,皮质缓慢波与心跳同步,类似于自然睡眠模式.
科学领域:
- 麻醉学 麻醉学
- 神经生理学 神经生理学
- 心脏病学 心脏病学
背景情况:
- 众所周知,普罗波会导致心血管抑郁和减缓神经生理活动.
- 现有的关于醇对心率的影响的文献是不一致的.
- 皮层缓慢波和心脏活动在propofol麻醉期间的关系还不清楚.
研究的目的:
- 为了研究波对心率的剂量依赖作用.
- 为了检查皮质缓慢波和心脏活动之间的关系在propofol麻醉下.
- 为了分析在普罗波输注期间心率变化变化的变化.
主要方法:
- 来自16名健康志愿者的心电图 (ECG) 和脑电图 (EEG) 数据的二次分析,这些志愿者接受了缓慢输液的propofol.
- 抽取心率,心率变化和个体缓慢的脑电图波.
- 来自AlphaMax试验的96名老年患者 (ASA身体状况II/III) 的心率数据分析.
主要成果:
- 普罗波输液剂量依赖地增加了心率 (+4.2±1.5次/分钟/[μg/ml]),这种效应也在老年患者中观察到.
- 普罗波降低了心电图R波幅,降低了心率变化中的高频偏交感活动.
- 皮层缓慢波与心跳相结合,峰值发生率在缓慢波发作之前约为450毫秒;缓慢波频率与心率相关.
结论:
- 在健康的志愿者和患者中,增加罗的度强烈地增加了心率,可能是通过降低了副交感性心脏抑制.
- 在propofol麻醉期间,皮层慢波与心律同步,这表明潜在的共同脑干发生器,类似于非REM睡眠.
更多相关视频
10:45Simultaneous Electroencephalography, Real-time Measurement of Lactate Concentration and Optogenetic Manipulation of Neuronal Activity in the Rodent Cerebral Cortex
Published on: December 19, 2012
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
相关概念视频
Electrophysiology of Normal Cardiac Rhythm
Brain Waves
Correlation between ECG and Cardiac Cycle
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
Propagation of Action Potentials
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Regulation of Heart Rates
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
