补充激活驱动通过巨细胞贩运和NETs形成的抗体介导输血相关的急性肺损伤
Saskia van der Velden1, Thijs L J van Osch1, Amina Seghier1
1Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
与输血相关的急性肺损伤 (TRALI) 涉及补体激活和巨细胞贩运. 针对补充系统可能为TRALI提供新的治疗策略,这是输血死亡的主要原因.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 病理生理学 病理生理学
背景情况:
- 与输血相关的急性肺损伤 (TRALI) 是输血相关死亡的重要原因.
- 目前,TRALI.没有有效的治疗方法.
研究的目的:
- 研究补充系统在TRALI病变发生过程中的作用.
- 探索TRALI的潜在治疗点.
主要方法:
- 利用与抗主要组织相容性复合物I类抗体的小鼠模型.
- 分析了被诊断患有TRALI的患者的血样本.
- 研究了TRALI诱导中的补充激活和Fc受体相互作用的功能.
主要成果:
- 在体外补充激活与体内抗体介导的TRALI相关.
- 特拉利诱导依赖于C5并涉及Fc介导的补充激活,而不是Fcγ受体.
- 在TRALI患者的血中观察到增加的补体激活和中性粒细胞外细胞陷 (NET) 标志物.
结论:
- 补体系统在TRALI的发病过程中起着至关重要的作用.
- 从肺部到血液的巨细胞贩运与TRALI中的Fc介导补充激活有关.
- NET形成与TRALI有关,这表明补充抑制是潜在的治疗策略.
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