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目前针对干细胞衍生的细胞外囊/细胞外体在心脏修复中的优化策略

Rongrong Wu¹, Xinyang Hu², Jian'an Wang²

¹Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, PR China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou 310009, PR China; Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou 310009, PR China.

Journal of molecular and cellular cardiology

|October 6, 2023

概括

来自干细胞的细胞外囊泡 (EVs),特别是外体,显示出治疗缺血性心脏病的前景. 优化它们的生产和设计以更好地提供它们是临床成功的关键.

科学领域:

心血管研究研究心血管研究
再生医学是一种再生医学.
生物技术是生物技术.

背景情况:

缺血性心脏病是全球主要的死亡原因.
干细胞疗法提供了心脏修复的潜力,主要是通过诸如细胞外囊泡 (EVs) 等膜因子.
外体细胞,一种EV,对于心肌修复至关重要,但在临床翻译方面面临挑战.

研究的目的:

在心脏修复中审查干细胞衍生的EVs/外体的生物发生和机制.
讨论高产量,生物活性EV/外体细胞生产策略的进展.
探索工程方法,以改进EV/外基因组定位和治疗功效.

主要方法:

文献综述侧重于干细胞衍生的EVs/心脏修复中的外体.
对EV/外体细胞生产和工程现有优化策略的分析.
检查在缺血性心脏病中EV/外体治疗的临床前和临床翻译数据.

主要成果:

来自干细胞的EVs/外体通过近信号传递调解心肌修复.
目前正在制定各种策略,以提高EV/外体细胞的产量,生物活性,指导和保留.
临床前和临床研究表明潜力,但突出显著的翻译障碍.

结论:

在治疗缺血性心脏病方面,EV/外体治疗具有显著的前景.
克服生产,生物活性和输送方面的挑战对于临床应用至关重要.
需要进一步的研究和开发,以促进EV/外体治疗的临床转化.

关键词:

心脏的修复心脏的修复外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.缺血性心脏病是一种心脏病.优化了战略的优化.干细胞是一种干细胞.

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