在儿科门静脉血栓塞的高发血栓后并发症率
M Vrijburg1, S Sari1, B G P Koot2
1Department of Pediatric Hematology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Thrombosis research
|October 6, 2023
概括
患有门静脉血栓症 (PVT) 的儿科患者中有一半患有门静脉高血压 (PH). 缺少血栓溶解和未引起的静脉血栓塞栓症 (VTE) 是PVT后PH发展的关键风险因素.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 肝病学 肝病学是一种肝病学.
- 血管医学 血管医学
背景情况:
- 门静脉血栓塞 (PVT) 是一种罕见的儿科疾病.
- PVT可以导致严重的并发症,如门高血压 (PH),肝肺综合征 (HPS) 和门肺高血压 (PPHTN).
- 儿童中这些血栓后并发症 (PTC) 的发生率和危险因素尚未得到充分确定.
研究的目的:
- 为了确定PH,HPS和PPHTN在PVT儿童中的发病率.
- 确定与这些PTCs发展相关的风险因素.
- 为儿童PVT患者提供长期随访和查策略的信息.
主要方法:
- 对患有PVT的儿科患者 (≤18岁) 的回顾性队列研究.
- 从1996年1月到2022年1月在阿姆斯特丹的Emma儿童医院UMC收集的数据.
- 分析的重点是确定PH,HPS和PPHTN的发病率和风险因素.
主要成果:
- 51%的儿科PVT患者患有PH;一个病例因PPHTN而复杂.
- 临床相关的出血发生在59.1%的PH患者中.
- PH的独立风险因素包括缺乏完全的血栓分离 (OR 24.3) 和未引起的静脉瘤 (OR 35.4).
结论:
- 大约有一半患有PVT的儿科患者会发展为PH.
- 缺少血栓解脱和未引起的静脉瘤是PH的重要独立风险因素.
- 在高危儿科PVT患者中,对PTC进行标准化,长期的随访和查至关重要.
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