合成和应用已批准用于治疗淋巴瘤的小分子
Yuan-Yuan Guo1, Jing-Yi Zhang2, Jin-Feng Sun3
1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China; Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, 450052, China.
European journal of medicinal chemistry
|October 6, 2023
概括
本综述涵盖了针对布鲁顿氨酸激酶 (BTK),酸酸3-激酶 (PI3K),基因组脱乙酸酶 (HDAC) 和DNA聚合酶 (POLA) 的新型淋巴瘤药物,以改善癌症治疗.
科学领域:
- 瘤学和免疫学
背景情况:
- 淋巴瘤是淋巴系统的癌症,涉及异常的淋巴细胞增殖.
- 目前的治疗方法包括化疗,辐射和向治疗.
结论:
- 针对特定分子通路的新药的开发对于有效的淋巴瘤治疗至关重要.
- 对新型化合物及其合成的进一步研究将促进淋巴瘤治疗.
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