预测早期 squamous 细胞癌局部切除后复发的预测因素
E Parkin1, S Kallipershad2, A Nasser2
1Department of Colorectal Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
概括
局部切除 (LE) 是早期门平细胞癌 (ASCC) 的可行的治疗方法,但复发风险取决于瘤分化,深度和边缘状况. 挽救治疗对于复发病例是有效的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 对早期门平细胞癌 (ASCC) 增加局部切除 (LE) 的使用,旨在减少化疗放射治疗 (CRT) 致病率.
- 组织学变量对LE后ASCC复发风险的影响尚不清楚.
研究的目的:
- 分析与LE治疗的T1/T2N0ASCC患者疾病复发的预测因素.
- 对LE后复发的ASCC进行救援治疗的有效性进行评估.
主要方法:
- 对164名早期 (T1/T2N0) ASCC患者的回顾性分析,这些患者在2010-2021年期间接受了LE治疗.
- 使用奇平方和克鲁斯卡尔-瓦利斯试验,探索临床病理因素和复发之间的关联.
主要成果:
- 在接受LE治疗的36名患者中,7名 (19.4%) 患有复发.
- 复发的重要预测因素包括瘤差异化 (p=0.024),瘤深度增加 (p=0.033),以及积极的R1切除边缘 (p=0.034).
- 所有复发病例都成功地用救援CRT,再切割或放射治疗治疗.
结论:
- 局部切除是早期ASCC的可行的治疗方法,对于复发可提供救援选择.
- 瘤分化,深度和边缘状况是用LE治疗早期ASCC的关键因素.
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