在晚上晚些时候出现的大血管封闭中,较大的缺血核心和较差的附带资产
Anirudh Sreekrishnan1, Steffen Tiedt2, Pierre Seners3
1Department of Neurology, Stanford Hospital, Palo Alto, CA, United States.
概括
大血管封闭性中风患者表现出缺血核心体积和附带状态的日间模式,在晚上8点左右达到顶峰. 这表明日常循环会影响中风的发展,影响治疗时间.
科学领域:
- 神经学 神经学
- 脑卒中医学 脑卒中医学
- 医疗成像医学成像
背景情况:
- 大脑输液组件表现出24小时的振荡.
- 之前的研究表明,在大血管封闭 (LVO) 患者中,缺血核心体积和中风发作时间之间存在昼间联系.
- 这项研究调查了缺血核心,附带状态 (低缩缺血区域 - HIR) 和中风发作时间之间的连续侧面关系.
研究的目的:
- 为了确定缺血核心体积和附带状态 (HIR) 是否与LVO患者中风发作时间呈现阴侧关系.
- 识别白血病核心体积和抵押状况达到峰值的一天中的时间.
主要方法:
- 来自四个国际中风中心的LVO患者的回顾性分析.
- 在中风发作后24小时内利用输液成像中的缺血核心体积和HIR.
- 进行了鼻状回归分析,根据年龄和成像时间进行调整.
主要成果:
- 分析了1506个LVO病例.
- 缺血核心体积显示了显著的白天变化 (p=0.003),在下午7:45左右达到顶峰.
- 低透性缺血区域 (HIR) 也因中风发作时间 (p=0.002) 有显著的变化,在晚上8点18分左右达到顶峰.
结论:
- 脑卒中发病时间与导致缺血核心发育的因素的日间变化有关.
- 研究结果强烈支持在缺血核心的发展中存在白天组件,晚上达到峰值.
- 结果对理解中风病理生理学和潜在地优化治疗时间有意义.
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