尿蛋白质链接补充激活与间歇性纤维化/管状缩在狼神经炎患者的患者
Shudan Wang1, Anna Broder2, Daming Shao3
1Division of Rheumatology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Seminars in arthritis and rheumatism
|October 6, 2023
概括
补充激活标记物,包括尿C3,CFI和C9-CD59比率,与狼性炎 (LN) 中的管管间纤维化有关. 这些发现表明,对于评估LN患者纤维化严重程度的潜在生物标志物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 内补充激活与狼性炎 (LN) 病变发生有关.
- 膜攻击复合体 (MAC) 的形成及其 CD59 的抑制在损伤中起作用.
- 补体激活和抑制之间的不平衡可能导致LN的间歇性纤维化和管管缩 (IFTA).
研究的目的:
- 在LN患者中调查尿补剂成分和IFTA之间的关联.
- 为了确定尿液中C9与CD59的比率是否与IFTA的严重程度相关.
- 探索补充激活标记物和纤维化关键介质之间的关系.
主要方法:
- 分析了46名经过活检证明的LN患者的尿样.
- 尿补剂成分和中度/重度与没有/轻度IFTA患者之间的C9-CD59比率的比较.
- 使用质谱学的蛋白质组学分析和与纤维化介质 (TGFβR1,TGFβR2,PDGFβ,PDGFRβ) 的相关性.
主要成果:
- 中度/重度IFTA的LN患者表现出尿C9与CD59比率的增加 (p=0.01).
- 在患有中度/重度IFTA的患者中观察到尿中C3 (p=0.02) 和CFI (p=0.01) 水平较高.
- 补充成分 (C3,C9,CD59,CFI) 与纤维化相关因素 (TGFβR1,TGFβR2,PDGFβ,PDGFRβ) 相相关.
结论:
- 尿中的C3,CFI和C9-CD59比率是LN中管间纤维化潜在的生物标志物.
- 这项研究提供了对补体失调在LN相关纤维化中的作用的见解.
- 这些发现突出了尿补体分析的潜力,用于评估LN进展.
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