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Updated: Jul 14, 2025

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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与自闭症相关的基因CHD8的异合性删除通过基因表达和染色质紧缩的广泛变化损害了突触功能

Xi Shi1, Congyi Lu2, Alba Corman2

  • 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute, Cambridge, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.

American journal of human genetics
|October 6, 2023
PubMed
概括

染色体螺旋酶DNA结合蛋白8 (CHD8) 突变会在自闭症谱系障碍 (ASD) 中损害神经元功能和基因表达. 恢复CHD8水平可以扭转这些缺陷,强调其在大脑发育中的关键作用.

关键词:
在ASD中,使用的是ASD.在CHD8中,克里斯普尔是什么意思?克里斯普尔是什么意思?自闭症自闭症是什么在这种情况下,染色染色素染色体域是一个染色体域.螺旋酸的使用方法是同源的同源性.神经发育的神经发育突触传输是突触传输的过程.

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