对 antraquinone 的遗传和产前发育评估
Jingjing Qu1, Yinjing Zhang1, Chunxia Liu1
1Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
Toxicology letters
|October 6, 2023
概括
茶中的 antraquinone 不是遗传毒性,但在高剂量时可以导致大鼠的发育毒性,影响母亲的健康和胎儿的发育. 需要进一步的研究来了解它的全部影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 遗传学 是一个遗传学.
背景情况:
- 人类是全球茶叶供应中发现的一种新兴污染物.
- 它的潜在原性和遗传毒性作用需要彻底调查.
研究的目的:
- 用多个测试来评估 antraquinone 的遗传毒性.
- 在大鼠模型中评估 antraquinone 对母亲健康和胎儿发育的影响.
主要方法:
- 基因毒性通过艾姆斯试验,微核试验和染色体异常研究来评估.
- 产前发育性毒性被评估在暴露于 antraquinone 的孕鼠中.
- 检查了对母亲的毒性,胎儿的发育和产性.
主要成果:
- 在标准测定中, antraquinone 没有显示变异性或基因毒性影响.
- 暴露在高剂量的母鼠体内体重和食物摄入量减少.
- 在最高剂量时,观察到胎儿内脏形的增加和两例孕产妇死亡.
结论:
- antraquinone 不是基因毒性,但会造成发育毒性的风险.
- 没有观察到的不良影响水平 (NOAEL) 确定为21.76 mg/kg BW.
- 最低观察到的不良影响水平 (LOAEL) 确定为217.6 mg/kg BW.
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