在鱼类过敏个体中对海鲜的真实世界敏感性和耐受性模式
Agnes S Y Leung1, Christine Y Y Wai2, Nicki Y H Leung2
1Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
The journal of allergy and clinical immunology. In practice
|October 6, 2023
概括
鱼类过敏在儿童中很常见,许多儿童可以耐受特定的鱼类,因为它们的β-白蛋白水平较低. 这突显了在海鲜过敏管理中需要个性化医疗的需要.
科学领域:
- 食物过敏研究 食物过敏研究
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 海鲜过敏是过敏反应的一个重要原因.
- 有限的现实世界数据存在于鱼类和贝类过敏呈现.
研究的目的:
- 研究对鱼类过敏个体的临床特征.
- 分析各种海鲜的免疫学概况和耐受性模式.
- 了解IgE对鱼类和贝类的敏感性.
主要方法:
- 招募了249名IgE介导鱼类过敏患者 (2016-2021年).
- 对鱼类和贝类进行了特定的IgE和皮肤刺伤测试.
- 评估了临床病史和最近的海鲜消费情况.
主要成果:
- 30%的人在挑战中对特定的鱼类 (草鱼,鱼,鱼,鱼) 有反应.
- 确定了与鱼类β-白蛋白水平相关的IgE敏感度梯度.
- 40%的人耐受某些鱼类 (例如,金枪鱼,鱼) 的β-parvalbumin较低;41%的人耐受甲类/软体动物,尽管有辅助敏感性.
结论:
- 鱼类过敏通常始于幼儿时期.
- 选择性耐受性较低的beta-parvalbumin鱼类是常见的.
- 对海鲜过敏需要精准医学方法.
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