癌症中EMT转录因子的转录调节
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Updated: Jul 14, 2025

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Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
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1Center for Medical Education and Sciences, Graduate School of Medicine, University of Yamanashi, Chuo-city, Yamanashi, Japan.
Seminars in cancer biology
|October 6, 2023
概括
表皮介质转换 (EMT) 涉及转录因子 (EMT-TF),如ZEB1/2,SNAIL和TWIST,推动癌症的进展. 本综述探讨了TGF-β如何在侵袭性癌症中维持和调节这些因素.
科学领域:
- 分子生物学分子生物学
- 癌症生物学 癌症生物学
- 细胞生物学 细胞生物学
背景情况:
- 表皮细胞-介质细胞过渡 (EMT) 是一种表皮细胞转变为介质细胞的过程.
- 在癌症中,部分EMT与入侵,转移和治疗抵抗有关.
- 包括ZEB1/2,SNAIL和TWIST在内的EMT转录因子 (EMT-TF) 是EMT的关键调节者.
研究的目的:
- 审查维持高水平EMT-TFs在侵袭性癌症中的分子机制.
- 了解TGF-β如何在癌症进展过程中提高EMT-TFs的调节.
主要方法:
- 对有关EMT,EMT-TF和癌症中TGF-β信号传递的现有文献的综述.
- 分析EMT-TF表达,介酶体标志物和癌瘤攻击性之间的相关性.
- 检查涉及TGF-β和其他信号分子的调节途径.
主要成果:
- ZEB1/2与介质细胞标记物和癌细胞的攻击性相关.
- TWIST和SNAIL与侵略性相关,但与介质细胞标记物没有很强的关系.
- 通常情况下,只有一个或一个EMT-TFs的子集在攻击性癌症中高度表达,除了肉瘤.
- TGF-β,通常与RAS信号一起,调节EMT-TF表达.
结论:
- EMT-TF在驱动侵袭性癌症表型方面发挥着至关重要的作用.
- 了解EMT-TFs的持续和上调表达对于向癌症进展至关重要.
- TGF-β信号传递是参与EMT-TFs上调的重要途径.
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