随机对照试验中使用佐洛皮作为大麻使用障碍的药物治疗
Dustin C Lee1, Nicolas J Schlienz1, Evan S Herrmann2
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Journal of substance use and addiction treatment
|October 6, 2023
概括
这项研究发现,佐尔皮-XR可能有助于减少大麻使用障碍 (CUD) 患者在治疗早期的睡眠障碍. 然而,在停止服用药物后,睡眠问题可能会再次出现,戒酒率在各组之间没有显著差异.
科学领域:
- 成 药物 药物 药物 药物
- 睡眠科学 睡眠科学
- 精神病学是一个精神病学.
背景情况:
- 睡眠障碍是大麻使用障碍 (CUD) 患者的常见问题.
- 经常使用大麻的人报告说,睡眠问题导致戒烟尝试失败.
- 需要对睡眠的客观测量及其与CUD治疗结果的关系.
研究的目的:
- 测量正在接受CUD治疗的成年人的睡眠模式.
- 为了调查催眠药物 (zolpidem-XR) 是否可以改善CUD治疗期间的戒断率.
- 评估皮-XR对CUD患者睡眠障碍的影响.
主要方法:
- 一个为期12周的随机对照试验,涉及127名患有CUD的成年人.
- 参与者接受了延长释放佐洛皮 (佐洛皮-XR) 或安慰剂,以及行为疗法和应急管理.
- 在家庭的多睡眠学 (PSG) 客观地测量了睡眠;自我报告措施和尿液药物测试评估了睡眠,失眠和禁欲.
主要成果:
- 与安慰剂相比,zolpidem-XR在治疗第一周减轻了睡眠障碍.
- 睡眠障碍在停药后在皮-XR组再次出现.
- 虽然皮-XR的戒断率较高 (27%对15%),但这种差异在统计学上并不显著.
- 治疗保留时间较差 (大约1~3个小时) 发现了50%的退学率) 和坚持的挑战.
结论:
- 皮-XR可能会暂时缓解早期治疗引起的CUD睡眠障碍.
- 索尔皮-XR治疗停止后,睡眠问题可能会出现.
- 需要进一步研究CUD的替代药物治疗和行为治疗方法,重点关注睡眠障碍的作用.
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