开源人工胰腺系统在临床支持时是安全有效的: 248名连续1型糖尿病患者的结果
Praveen Samuel1, Nabeel Khan1, Gerri Klein1
1BCDiabetes, Vancouver, British Columbia, Canada.
Canadian journal of diabetes
|October 6, 2023
概括
支持的开源人工胰腺系统 (SOSAPS) 安全地改善了1型糖尿病患者的葡萄糖控制和生活质量. 临床支持的SOSAPS管理导致了更好的射程时间,A1C和整体幸福感.
科学领域:
- 内分泌学 在内分泌学.
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 1型糖尿病 (T1D) 管理传统上依赖于手动胰岛素调整.
- 技术进步为改善血糖控制和提高生活质量提供了潜力.
- 开源人工胰腺系统 (APS) 是糖尿病自我管理的一个新兴领域.
研究的目的:
- 评估与T1D患者在临床安装和管理支持的开源人工胰腺系统 (SOSAPS) 相关的安全性,血糖结果和生活质量 (QoL).
- 评估诊所提供的无成本SOSAPS计划的可行性和影响.
- 在现实环境中比较不同的SOSAPS平台 (Loop,iAPS,Android-APS).
主要方法:
- 在加拿大糖尿病中心使用SOSAPS的248名T1D患者的回顾性队列研究.
- 提供SOSAPS技术精通的患者愿意同意,硬件成本由患者承担.
- 临床工作人员免费提供安装和管理;患者使用Loop,iAPS或Android-APS.
主要成果:
- 在17个月的时间里,发生了3次严重的低血糖症,没有糖尿病酸性酸症 (DKA).
- 观察到显著的改善:在范围内的时间 (TIR) 增加了16% (64%至80%),范围以下的时间 (TBR) 减少了1.0% (3.5%至2.5%).
- 平均传感器葡萄糖 (MSG) 降低 (9.0至8.1 mmol/L),葡萄糖管理指标 (GMI) 改善 (7.3%至6.7%),HbA1c降低 (7.2%至6.7%). 生活质量得分也得到了改善.
结论:
- 临床支持的SOSAPS,为患者提供免费服务,是T1D管理的安全和有效方法.
- SOSAPS显著提高血糖控制,通过改善TIR,GMI和A1C证明了这一点.
- 该计划对患者的生活质量产生了积极的影响,强调了可访问的人工胰腺技术的好处.
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