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微质衍生的CCL20在心室内出血后恶化神经发生

Nan Yao¹, Yulin Li¹, Jinrui Han¹

¹Department of Neurology, Institute of Neuroimmunology, Tianjin Medical University General Hospital, Tianjin, China.

Experimental neurology

|October 6, 2023

概括

腹腔内出血 (IVH) 通过激活微质细胞,损害了大脑的修复. 向微质细胞或CC化学因子连接体20 (CCL20) 可能改善神经发生和IVH后的功能恢复.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
再生医学是一种再生医学.

背景情况:

腹腔内出血 (IVH) 通常从脑内出血 (ICH) 延伸,导致不良结果.
缺乏IVH诱导的大脑损伤的有效管理策略.

研究的目的:

为了研究微质和CC化基因配体20 (CCL20) 在IVH后的神经发生和神经修复中的作用.
探索减轻IVH相关脑损伤的潜在治疗点.

主要方法:

使用了IVH的小鼠模型.
给药PLX3397,一个殖民地刺激因子1受体 (CSF1R) 抑制剂,以耗尽微质细胞.
研究了阻断CCL20对神经干细胞 (NSC) 和信号通路的影响.

主要成果:

IVH诱导神经发生障碍,持续的微质激活,以及腹下区域 (SVZ) 的细胞死亡.
使用PLX3397的微质枯竭促进了IVH小鼠的神经发生和改善功能结果.
在SVZ中微质衍生的CCL20升高会影响NSC的增殖和生存,可能通过Akt/mTOR/NF-κB通路.

结论:

微质在IVH后的神经发生和神经修复中起着有害的作用.
CCL20有助于IVH诱导的神经炎症和神经损伤.
向微质或CCL20为IVH提供了一个有希望的治疗途径.

关键词:

CCL20 CCL20 CCL20 CCL20 CCL20 CCL20 CCL20 CCL20 室内静脉出血室内静脉出血微质细胞中的微质细胞神经新生是神经发生的过程.腹腔下部区域的损伤

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