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电生理学证据表明,TRPM3是慢性腰部疼痛的潜在脊柱敏感化候选者

Dan Wang¹, Rolf-Detlef Treede², Georg Köhr³

¹Department of Anesthesiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China; Department of Neurophysiology, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany.

Neuroscience letters

|October 6, 2023

概括

孕醇硫酸盐 (PregS) 激活脊髓中的TRPM3通道,增强突触强度. 这一发现揭示了神经内分泌信号与疼痛之间的联系,可能导致慢性腰部疼痛.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
脊髓生理学脊髓生理学

背景情况:

潜在的脊柱敏感化是慢性腰部疼痛 (LBP) 的关键早期机制.
背部根 (DRG) 神经元中的TRPM3通道介导信号传递,这对于这种敏感性至关重要.
在脊髓中TRPM3激活的 postsynaptic 效应仍然在很大程度上未被探索.

研究的目的:

为了研究TRPM3激活在脊髓表面背角的后突触后果.
确定TRPM3在中介神经内分泌和感知信号中的作用.

主要方法:

在成年大鼠的急性脊髓切片中进行了电生理学记录.
使用TRPM3主激素孕醇硫酸盐 (PregS) 来评估其对神经元活动的影响.

主要成果:

注PregS显著增加了I层和II层神经元中自发后突触电流的频率,但不是振幅.
这种效应在洗后是可逆的,这表明了前突触机制.
功能TRPM3通道在表面的背角中以预突触方式表达.

结论:

孕S诱导的TRPM3激活增强了脊柱突触强度.
TRPM3在神经内分泌信号传递和知觉之间起着调解作用.
这种机制可能与慢性压力和增加PregS生物合成相关的慢性腰痛有关.

关键词:

慢性压力是一种慢性压力.背部根腺神经元的神经元.这是神经类固醇.孕诺龙硫酸盐是什么孕诺龙硫酸盐是什么自发的突触后电流是自发的.在TRPM3中,TRPM3是什么?

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Thermosensation

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