相关实验视频

Updated: Jul 14, 2025

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds

Published on: November 6, 2015

在急性Plasmodium relictum感染的房子 (Passer domesticus) 中,下丘脑-垂体-上腺轴功能,免疫力和葡萄糖的变化

T R Kelly¹, A L Cannon¹, K R Stansberry¹

¹Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

General and comparative endocrinology

|October 6, 2023

概括

生理反应的个体变化影响着鸟类疟疾的动态. 这项研究发现,虽然大多数宿主指标没有预测耐药性,但感染的子显示出抗炎特征和改变的皮质反,提供了对鸟类疾病耐药性的见解.

科学领域:

*野生动物免疫学和宿主-寄生虫相互作用.
* 鸟类生理学和疾病病理学.

背景情况:

* 宿主生理学的个体变化会影响疾病动态,但野生动物的潜在机制尚不清楚.
* 脑下垂体上腺 (HPA) 轴是应激反应和免疫功能的关键调节器.

研究的目的:

* 测试HPA轴是否介导歌鸟对鸟类疟疾的宿主耐药性和耐受性.
* 评估葡萄糖皮质类药物与对Plasmodium relictum感染的耐药性之间的关系.

主要方法:

*用Plasmodium relictum对家禽 (家禽) 进行实验性接种.
* 在感染前和感染期间对皮质,免疫功能,血糖和肝细胞因子表达 (IFN-γ,TNF-α,IL-10,TGF-β) 的量化.
*对HPA轴负反有效性的评估.

主要成果:

*瘤亡因子-α (TNF-α) 肝脏表达与寄生虫血症正相关.
* 小在疟疾感染期间显示出抗炎特征.
*干扰素 (IFN-γ) 和葡萄糖水平与感染鸟类的免疫参数有关.
* 皮质的负反强度在急性感染期间在垂体水平上增加.

结论:

* 发现了鸟类疟疾寄生虫与宿主免疫系统之间的新型关系.
*HPA轴和炎症反应在禽疟疾的急性阶段起作用.
* 发现有助于了解疾病病理学,并为处于危险的禽类动物的保护策略提供信息.

关键词:

细胞因子 (cytokines) 是一种细胞因子.葡萄糖皮质类药物是什么炎症炎症是一种炎症.疟疾:疟疾是一种疾病.负面的反是负面的反.电阻电阻电阻电阻电阻电阻

更多相关视频

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

相关概念视频

Hypothalamic-Pituitary Axis

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

Physiological Foundation of Stress

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...