来自Lycii fructusus的四种多糖的结构特征和结构活性关系
Xiaofei Liang1, Mengqiu Liu1, Yan Wei1
1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
International journal of biological macromolecules
|October 6, 2023
概括
分析了Lycii fructus多糖 (LFPs) 的结构-活性关系. 研究结果显示,银河酸含量与抗氧化活性相关,而分支链则有助于抗衰老效应.
科学领域:
- 葡萄糖生物学和碳水化合物化学
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多糖的结构-活性关系对于理解生物功能至关重要.
- 果多糖 (LFP) 已知具有潜在的健康益处,但其结构基础尚未完全阐明.
研究的目的:
- 为了研究来自Lycii fructus的同质多糖的结构-活性关系.
- 为了比较评估不同LFP结构的抗氧化和抗衰老活动.
主要方法:
- 四种同质的LFPs (一个中性,三个酸性) 的净化和结构特征.
- 气色谱-质谱 (GC-MS) 测定单糖化合物的组成.
- 甲基化分析和核磁共振 (NMR) 谱学用于结构阐明.
- 在体外测定抗氧化和抗衰老活动.
主要成果:
- LFPs表现出类似的葡萄糖类型,但比例不同.
- 核磁共振检测出了阿拉比诺,拉姆诺和同的域名.
- 抗氧化活性与银酸 (GalA) 含量正相关.
- 中性多分支链与抗衰老活性有关.
结论:
- 本研究提供了第一个对LFP结构及其生物活动的比较分析.
- 银酸含量是LFPs抗氧化性质的关键.
- 中性分支链与LFPs的抗衰老作用有关.
- 这些发现为Lycii fructus的工业发展和健康价值提供了洞察力.
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