孕期暴露于环境细颗粒物会破坏母亲的肝脂代谢
Yunlu Wu1, Yirun Wang1, Wenhui Zhang2
1School of Public Health, Zhejiang International Science and Technology Cooperation Base of Air Pollution and Health, Joint China-US Research Center for Environment and Pulmonary Diseases, Zhejiang Chinese Medical University, Hangzhou, China.
Chemosphere
|October 6, 2023
概括
孕期暴露于细颗粒物 (PM2.5) 改变母亲肝脏脂质代谢不同于非怀孕小鼠. 这项研究揭示了PM2.5在怀孕期间破坏脂质处理,影响弱势群体.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢过程中的代谢.
背景情况:
- 怀孕带来了独特的生理变化,并增加了对环境污染物暴露的脆弱性.
- 环境细颗粒物 (PM2.5) 对孕期母亲脂质代谢的影响在很大程度上仍未被描述.
- 了解这些影响对于保护母亲和胎儿健康至关重要.
研究的目的:
- 研究孕期暴露于PM2.5对母亲脂质代谢的影响.
- 为了阐明PM2.5诱导的肝脂处理在怀孕期间的改变的潜在机制.
- 为了比较PM2.5暴露在怀孕和非怀孕的雌性小鼠中的代谢效应.
主要方法:
- 怀孕和非怀孕的C57BL/6小鼠从妊娠0.0日开始暴露在环境PM2.5或过空气中.
- 评估的体重,身体成分,耐葡萄糖性,以及血清/肝脏脂质概况.
- 分析了参与肝脏脂质代谢 (吸收,合成,氧化,输出,脂解) 的关键酶和蛋白质的表达.
主要成果:
- 暴露于PM2.5并没有显著影响怀孕小鼠的体重或组成.
- 怀孕的小鼠表现出更好的葡萄糖耐受性,而非怀孕的小鼠表现出更高的禁食葡萄糖.
- 孕期PM2.5暴露改变了肝脏的脂质代谢,增强了脂质合成和吸收途径,同时抑制了怀孕小鼠的脂质输出,在非怀孕小鼠中具有对比的影响.
结论:
- 怀孕期间的PM2.5暴露与非怀孕状态相比,对母亲的脂质代谢有不同的影响.
- 孕期PM2.5暴露会破坏肝脏脂质代谢,影响吸收,合成,氧化和出口的途径.
- 这些发现提供了PM2.5在怀孕期间对肝脂代谢的不良影响的毒理证据,突出了脆弱人群的风险.
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