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在中央杏仁体中存在一个远程恐惧记忆录
Robert J Hammack1,2, Victoria E Fischer1,3, Mary Ann Andrade1
1Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Learning & memory (Cold Spring Harbor, N.Y.)
|October 6, 2023
概括
在恐惧记忆形成过程中激活的中枢杏仁体 (CeA) 神经元的一个子集在回忆过程中被重新激活,这有助于远程恐惧记忆和行为. 这种CeA刻录对于检索恐惧记忆至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 恐惧记忆的形成和回忆涉及到中央杏仁体 (CeA).
- 一个远程恐惧记忆录位于前底侧桃体 (aBLA).
- 下游CeA神经元在远程恐惧记忆回忆中的作用尚不清楚.
研究的目的:
- 调查在恐惧记忆形成过程中激活的CeA神经元是否在远程记忆检索过程中被重新激活.
- 为了确定CeA图形是否参与远程恐惧记忆回忆和相关行为.
- 测试CeA神经元有助于远程恐惧记忆回忆的假设.
主要方法:
- 在TRAP2;Ai14小鼠中的上下文恐惧调节以识别激活的CeA神经元 (TRAPing).
- 在远程记忆回忆期间使用Fos免疫组织化学量化CeA神经元激活.
- 双重标记用于识别在记忆形成和回忆过程中激活的CeA神经元.
主要成果:
- 受到恐惧条件的小鼠表现出强烈的恐惧记忆行为 (结).
- 在受到恐惧条件的小鼠中观察到更多的激活和重新激活的CeA神经元.
- 被 TRAPed CeA 神经元群体的大小与回忆期间的结行为相关.
结论:
- 恐惧记忆形成强烈地激活了CeA神经元.
- 一个CeA神经元的子集,主要在囊子部分 (CeAC),可能参与存储和检索远程恐惧记忆.
- 这些CeA神经元有助于与远程记忆回忆相关的恐惧类行为.
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