血清活性对性,潜伏性和可能的交叉反应性EBV抗原出现平均在MS诱导临床前神经轴突损伤前10年
Daniel Jons1, Viktor Grut2, Tomas Bergström3,4
1Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden daniel.jons@vgregion.se oluf.andersen@neuro.gu.se.
Journal of neurology, neurosurgery, and psychiatry
|October 6, 2023
概括
爱斯坦-巴尔病毒 (EBV) 感染比多发性硬化症 (MS) 和轴突损伤早10年. 在轴突损伤增加之前出现了潜在和临床EBV血清活性和ANO2抗体,支持EBV.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 多发性硬化症 (MS) 与爱斯坦-巴尔病毒 (EBV) 感染有关.
- 无症状的轴突损伤也可能跟随EBV感染.
- 在临床前时间表和EBV抗原类型中需要进一步确认.
研究的目的:
- 调查EBV感染与MS临床前标志物之间的时间关联.
- 在MS发作之前检查血清活性对潜伏和溶性EBV抗原和阿诺胺2 (ANO2).
- 为了将EBV血清活性与临床MS诊断前的神经轴损伤标志物 (sNfL) 水平相关联.
主要方法:
- 对669个前MS血清样本进行了病例控制研究.
- 测量了针对EBNA1 (潜伏),gp350 (lytic) 和ANO2的抗体.
- 还评估了血清神经丝光链 (sNfL) 水平,这是轴突损伤的标志物.
主要成果:
- 在MS发作前15-20年,EBNA1 (潜伏) 血清活性增加,随后是gp350 (lytic) 血清活性.
- 在MS前的病例中,ANO2血清阳性发生在EBNA1血清阳性之后.
- 轴突损伤 (sNfL) 在EBV感染后大约十年增加,特别是在血清阳性前MS个体中.
结论:
- 在MS发病前10年,EBV血清活性 (潜伏和溶性) 和ANO2抗体可检测到.
- 在临床MS之前的十年里,轴突损伤增加,特别是在EBV阳性个体中.
- 这些发现支持潜伏EBV在MS病变发生过程中的作用假设.
相关概念视频
00:42Cross-reactivity
31.2K
Overview
31.2K
01:29Immune Response Against Viral Pathogens
804
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
804
01:23Immunological Memory
644
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
644