针对SARS-CoV-2尖端特异的TFH细胞在感染和接种疫苗的个体中表现出独特的反应
Rongzhang He1,2, Xingyu Zheng1,2, Jian Zhang2
1College of Basic Medical Sciences, Hengyang Medical School, University of South China & MOE Key Lab of Rare Pediatric Diseases, 421001, Hengyang, China.
Signal transduction and targeted therapy
|October 6, 2023
概括
对SARS-CoV-2的长期保护依赖于T毛囊辅助细胞 (TFH). 尖端特异性CXCR3+TFH细胞对于感染和接种疫苗后持久抗体反应至关重要,指导未来的疫苗开发.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 长期的幽默免疫对于预防SARS-CoV-2再感染至关重要.
- 毛囊T辅助细胞 (TFH) 调节中和抗体的产生和B细胞的分化.
- 在COVID-19康复者和接种疫苗的人中,TFH细胞子集的寿命和功能尚不清楚.
研究的目的:
- 研究CXCR3+和CXCR3-TFH细胞子集在应对SARS-CoV-2感染和接种疫苗时的不同作用和耐久性.
- 确定增强剂对TFH细胞群和抗体反应的影响.
- 阐明不同TFH细胞子集在抗体分泌细胞分化中的功能能力.
主要方法:
- 在SARS-CoV-2感染和无活化疫苗接种后,对个体的尖端特异性CXCR3+和CXCR3-TFH细胞反应的分析.
- 评估TFH细胞子集与抗体反应之间的相关性.
- 对第三次疫苗增剂剂对TFH细胞种群的影响的评估.
- 功能性测试比较TFH细胞子集诱导抗体分泌细胞 (ASCs) 的能力.
主要成果:
- 无论是SARS-CoV-2感染还是非活化疫苗都会诱导不同的CXCR3+和CXCR3- TFH细胞反应.
- 与CXCR3- TFH细胞相比,尖端特异性的CXCR3+ TFH细胞表现出更为主导和持续的反应,与抗体水平呈正相关性.
- 第三次疫苗增剂剂量优先扩大CXCR3+ TFH细胞子集,增强抗体成熟和效力.
- 尖端特异性CXCR3+TFH细胞显示出促进尖端特异性ASC分化的优越能力.
结论:
- 持续性和功能性尖端特异性CXCR3+TFH细胞对于维持抗体水平和在SARS-CoV-2感染和接种疫苗后启用召回反应至关重要.
- 这些发现强调了CXCR3+TFH细胞在建立长期保护性免疫记忆中对SARS-CoV-2的重要性.
- 该研究为开发引发强大和持久的T细胞介导免疫力的疫苗提供了洞察力.
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