左心室透析功能障碍中的体积标志物和腹腔透析患者的不良结果:一个前性队列研究
Shoubo Xiang1, Mingliang Zuo2, Yan Deng3
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Scientific reports
|October 6, 2023
概括
在透析患者中,左心室透析功能障碍 (LVDD) 与更糟糕的结局有关. 监控 E/E 的情况.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 左心室透析功能障碍 (LVDD) 是慢性病 (CKD) 透析患者的常见并发症.
- LVDD与心血管疾病发病率和死亡率的增加有关.
- 腹腔透析 (PD) 是对末期脏疾病的常见治疗方法.
研究的目的:
- 调查通过E/E'比率评估的透缩功能障碍与PD患者的不良结果之间的关联.
- 在这个人群中确定LVDD的预测因子.
主要方法:
- 对148名PD患者进行前性研究.
- 使用E/E'比率对腹功能进行心声学评估.
- 临床特征,体积状态标志物和生存数据的分析.
- 卡普兰-梅尔生存分析和考克斯比例危险回归.
主要成果:
- 具有E/E'比率≥15的患者表现出更高的女性性别率,更长的透析年限,增加左心房体积和动能,较低的E'速度,以及更高的LV缩和体积标志物.
- 较高的E/E'比率与较差的存活率和心力衰竭风险增加有关,特别是在非糖尿病患者中.
- ECW/ICW比率与LVDD有很强的关联,而E/E'比率独立地预测了整体死亡率.
结论:
- 在PD患者中,E/E'比率是不良结果的重要预测指标,包括死亡率和心力衰竭.
- 通过E/E'比率监测透支功能对于PD患者的风险分层和预后至关重要.
- 用ECW/ICW比率表示的液体过载与PD患者的LVDD有关.
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